Ĭurrently, renal lesions are evaluated using contrast-enhanced computed tomography (CT) and magnetic resonance imaging (MRI). Moreover, 30-50% of kidney-localized RCC eventually metastasize with a median survival of 10.2 months and a five-year survival rate under 15%. Due to a paucity of effective screening tests, approximately a third of RCC patients present with metastasis at the time of diagnosis. Unfortunately, many RCC tumors are asymptomatic and non-palpable in their early stages therefore, greater than 50% of RCC tumors are incidentally detected by diagnostic imaging. Renal cell carcinoma (RCC) is the most common form of adult renal cancer, accounting for 85-90% of kidney neoplasms and ~3% of adult malignancies. However, low b-value DW-MRI displayed an overall superior diagnostic accuracy over standard b-value DW-MRI. Standard b-value DW-MRI showed a superior specificity but an approximately equivalent sensitivity to low b-value DW-MRI in detecting RCC lesions in the kidney. The SROC curve of standard b-value DW-MRI displayed an AUC of 0.61 and a Q*index of 0.59, while the SROC curve of low b-value DW-MRI displayed an AUC of 0.68 and a Q*index of 0.64. Standard b-value DW-MRI displayed a pooled sensitivity of 0.59 (95% confidence interval (CI): 0.51-0.67) and a pooled specificity of 0.50 (95% CI: 0.30-0.70), while low b-value DW-MRI displayed a pooled sensitivity of 0.58 (95% CI: 0.48-0.63) and a pooled specificity of 0.23 (95% CI: 0.09-0.44). Resultsįour articles that complied with all inclusion and exclusion criteria were selected for data extraction and analysis (n = 248 lesions in 266 patients).

In addition, a summary receiver operating characteristic (SROC) analysis was performed. MethodĪfter a systematic review of the available literature, studies were included that reported b-values, used a histopathological reference standard, and allowed construction of 2 × 2 contingency tables for detection of RCC lesions using DW-MRI. We sought to determine the comparative diagnostic performance of standard b-value (800–1000 s/mm 2) versus low b-value (400–500 s/mm 2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of renal cell carcinoma (RCC).

Clearview value metric mri